US Airways, Inc. is the sixth largest airline in the United States. A member of the Star Alliance, it has a fleet of 357 mainline jet aircraft and 329 regional jet and turbo-prop aircraft connecting 240 destinations in North America, Central America, the Caribbean, Hawaii, and Europe. As of May 2008, US Airways employs 36,632 people worldwide and operates 3,512 daily flights (1,392 US Airways Mainline, 2,120 US Airways Express as of May 2008). The US in US Airways represents "United States". The airline was known previously as USAir from 1979 to 1996. It was purchased by America West in 2005; although the combined group is now run from America West's base in Tempe, Arizona, and has adopted some of its business practices, the merged airline uses the US Airways brand, and the parent company is now known as US Airways Group.

US Airways operates hubs in Charlotte, Philadelphia and Phoenix. US Airways also maintains focus city operations at Ronald Reagan Washington National Airport in Washington, DC, McCarran International Airport in Las Vegas, Nevada, LaGuardia Airport in New York, and Logan International Airport in Boston.

The airline operates the US Airways Shuttle, a US Airways brand which provides hourly service between key Northeastern markets. Regional airline service is branded as US Airways Express, operated by contract and subsidiary airline companies.